Dasatinib-induced pulmonary arterial hypertension unresponsive to PDE-5 inhibition.

We read with interest the article ‘‘Src tyrosine kinase is crucial for potassium channel function in human pulmonary arteries’’ by NAGARAJ et al. [1]. The authors elegantly demonstrated that in physiological conditions, a low pulmonary vascular tone is maintained by Src family tyrosine kinase (SrcTK) and that inhibition of SrcTK will lead to vasoconstriction of pulmonary resistance arteries and thus to an increase in pulmonary artery pressure [1].